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dissertation (3)


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2023 (3)

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Dissertation
Nutritional status in frail older patients with cancer: a multicenter study

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Background: Malnutrition is prevalent among frail older persons with cancer and is associated with poor health outcomes. Nutritional advice plays a vital role in addressing malnutrition in this population. Further research is needed regarding the nutritional status of frail older persons with cancer, as well as geriatric recommendations and interventions aimed at preventing or treating malnutrition within this group. Objective: This study aims to assess the nutritional status of frail older persons with cancer and offer a comprehensive overview of geriatric recommendations and interventions concerning nutritional status. Additionally, it will provide insights into weight changes and the nutritional status across different tumor types and timepoint of inclusion. Methodology: This secondary data analysis, focusing on nutritional status and related recommendations and interventions, uses previously collected data from a large-scale prospective multicenter observational cohort study involving older persons with cancer (n=8451; 22 Belgian hospitals; November 2012 - February 2015). Patients aged 70 and above with cancer were included. They were approached by a trained healthcare provider during a hospital visit for treatment decisions. Patients underwent frailty screening using the G8 screening instrument. A geriatric assessment followed if the G8 screening scored ≤14 out of 17. Patient, socio-demographic and clinical characteristics were collected. Nutritional status was assessed using the Mini Nutritional Assessment - Short-Form (MNA-SF). At baseline, MNA-SF data were available for 5818 patients. The MNA-SF score ranges from 0 to 14: ≥12 indicates normal, 8-11 indicates risk of malnutrition, ≤7 indicates malnutrition. Results: The prevalence of the nutritional status using the MNA-SF shows that 17,72% had a normal nutritional status, 51,66% were at risk of malnutrition and 30,61% were malnourished. Over 58.53% of older persons with cancer received geriatric recommendations on nutritional status. Among those receiving recommendations, primary interventions were referral to a dietician, followed by referral to a geriatrician and geriatric consulting team. After three months 51.63% received nutrition-related recommendations. Dietician remained the primary source of intervention with an adherence rate of 81,67% compared to baseline. Conclusion: This study reveals a high prevalence of the risk of malnutrition among vulnerable older individuals with cancer, underscoring the need for early identification and intervention strategies to address nutritional challenges. The multidisciplinary approach involving healthcare professionals specialized in geriatric care, nutrition, and related fields is crucial for optimizing care in this population.

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Dissertation
Predictiemodellen voor postoperatief delirium bij de chirurgische patiënt

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SAMENVATTING Achtergrond: Een delirium kan verschillende gevolgen hebben op korte en lange termijn. Het tijdig inzetten van preventieve maatregelen kan deze gevolgen voorkomen of beperken. Om de patiënten die een risico hebben op postoperatief delirium te detecteren kan gebruikgemaakt worden van predictiemodellen. Doel: Een systematic review die de bestaande predictiemodellen voor postoperatief delier en hun validiteit in kaart brengt. Design: Een systematic review. Databronnen: Er werd gezocht in de databanken van Pubmed, Cinahl, Web of Science en Embase. Dit vanaf het ontstaan van de databanken tot zondag 26 juni 2022. Methode: Prospectieve studies met gehospitaliseerde volwassen patiënten op niet-intensieve chirurgische afdelingen werden geïncludeerd. Gestandaardiseerde data extractie en kwaliteitsbeoordeling gebeurde door één onderzoeker. Zevenentwintig artikelen werden geselecteerd voor inclusie. Resultaten: Er werden 28 predictieve modellen gevonden. De meeste modellen zijn onderzocht bij patiënten van 60 jaar en ouder (n=23). Vier studies onderzochten patiënten jonger dan 60 jaar. Predictieve modellen voor postoperatief delirium (POD) werden voornamelijk bestudeerd in een steekproef met patiënten die spinale of orthopedische chirurgie ondergingen. De modellen omvatten 1 tot 9 risicofactoren. De meest voorkomende risicofactoren opgenomen in de modellen zijn cognitief functioneren, leeftijd en depressie. Conclusie: De meeste predictiemodellen baseren zich op één soort chirurgie en dienen dus nog gevalideerd te worden in een bredere populatie. (n=19) Eénentwintig modellen werden gevalideerd. De sensitiviteit in de gevalideerde modellen varieert tussen 11,9% en 93,2%. De specificiteit varieert tussen de 41,8% en 99%. Voor 16 modellen werd een AUC waarde gerapporteerd. De AUC waarden variëren tussen 0,695 en 0,938. Sommige predictiemodellen zullen in de praktijk moeilijk implementeerbaar zijn door de uitgebreidheid of door de aard van de opgenomen risicofactoren. Relevantie voor praktijk: De resultaten van deze review kunnen als basis dienen voor verder onderzoek naar implementatie van predictiemodellen in de klinische praktijk.

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Dissertation
A scoping review on economic evaluations and financial consequences related to telehealth services for unplanned care in older adults.

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Background: In recent decades, the provision of healthcare remotely increased substantially. The recent Covid-19-pandemic has also highlighted the need for telehealth services for our more vulnerable inhabitants. Objectives: The aim of our study was to give an overview of the current state of the literature in the context of economic evaluations and financial consequences related to the use of telehealth services by older adults who needed unplanned care. Methods: A scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Scoping Reviews (PRISMA-ScR). We searched for articles published between 2012 and 2022 in the electronic databases PubMed, Web of Science, Embase, Cochrane Central database and CINAHL. Primary studies were included when they reported on telehealth and unplanned care in older adults if the financial aspects were mentioned. Results: Out of the 12618 articles screened, only five studies could be retained for analysis. Two of these articles contained a full economic evaluation. The other three only described costs generated by their telehealth intervention. In all articles, there was a mention of cost savings due to reduced hospitalization or visits to emergency services. Conclusion: The costs and benefits described in the included articles were highly variable. The limited information we could generate from the articles points us to the need for more research on this topic.

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